A new study demonstrates what researchers consider conclusive evidence that the red wine compound resveratrol directly activates a protein that promotes health and longevity in animal models.
What’s more, the researchers have uncovered the molecular mechanism for this interaction, and show that a class of more potent drugs currently in clinical trials act in a similar fashion. Pharmaceutical compounds similar to resveratrol may potentially treat and prevent diseases related to aging in people, the authors contend.
A group of medical researchers at the University of California at Berkeley has found a protein that is able to rejuvenate aged blood stem cells...
The ravages of aging appear to be related to oxidative stress combined with telomere exhaustion, along with many other known and unknown factors. The subject of the new Berkeley study is a class of proteins called sirtuins that are known to play a central role in regulating aging and longevity in many non-human models (such as mice).
The root cause of aging is very straightforward: we age because our cells age.
In 1961, Leonard Hayflick, a researcher at the Wistar Institute in Philadelphia, discovered that there was a limit to the number of times a human cell could divide.1 After about 70 divisions, a cell derived from embryonic tissue enters a stage where its ability to divide slows and eventually stops. This stage is called cellular senescence. Hayflick also observed that the number of times a cell could divide was governed by the age of the cells: cells from a twenty-year-old could divide more times than cells from a fifty-year-old, which in turn would divide more times than cells from a ninety-year-old.
Ray and Terry's 's insight:
An interesting discussion on telomerase and aging. We are not yet sure whether attempting to increase telomere length, particularly with current available methods, is the answer to aging. There is some indication that cancer can be triggered by these efforts.
The research is promising, but we cannot yet recommend the therapies.
An unlikely, decadelong journey that began with the discovery of a rapidly aging mouse has led scientists to a protein that seems to protect animals from cancer and other scourges of old age—with no apparent downsides. There are still lots of mysteries about the protein, called BubR1, but the work offers clues about how protecting chromosomes can enhance health.
The tiny freshwater polyp Hydra is a remarkable creature. It does not show any signs of ageing and appears to be immortal. Researchers from Kiel University have examined this phenomenon and uncovered an important link to the ageing process in humans that could lead to the development of advanced rejuvenation therapies.
How does the polyp Hydra do this? It accomplishes the feat of apparent immorality by reproducing through budding rather than mating. Each polyp contains stem cells capable of continuous proliferation. Without this endless supply of regenerating stem cells, the animals could not reproduce.
A new method of growing cardiac tissue is teaching old stem cells new tricks.
The discovery, which transforms aged stem cells into cells that function like much younger ones, may one day enable scientists to grow cardiac patches for damaged or diseased hearts from a patient’s own stem cells — no matter what age the patient — while avoiding the threat of rejection.
The red wine compound resveratrol could help older people to battle against motor deficiencies that lead to mobility problems and increased risks of falls, according to new research in mice.
The older mice in the study received resveratrol for weeks. By the fourth week, these mice had improved mobility, on par with the younger mice.
Taking aspirin daily may help protect against cancer but the effect seems weaker than previously thought, according to a U.S. study that included a decade's worth of data from more than 100,000 people.
Gerontologists and demographers have argued about this for a long time, with the balance of opinion heavily influenced by the changes seen in the wealthiest nations’ “survival curves” — graphs showing, broadly speaking, the proportion of an initial population that survived to a given age.
People who restrict their caloric intake in an effort to live longer have hearts that function more like those in people who are 20 years younger.
Researchers at Washington University School of Medicine in St. Louis have found that a key measure of the heart's ability to adapt to physical activity, stress, sleep and other factors that influence the rate at which the heart pumps blood, doesn't decline nearly as rapidly in people who have significantly restricted their caloric intake for an average of seven years.
Alzheimer's may strike 100 million people by 2050. Gregory Petsko, Chair of the Department of Biochemistry at Brandeis University, asks: We know our populati...
Research extended mouse lifespan by up to 24% using gene therapy.
The therapy also decreased the signs of aging. For example, it improved muscle health and delayed the diseases of aging such as osteoporosis and insulin resistance.
Researchers at Yale University have found a way to effectively turn back the clock and make an old brain young again.
As we enter adulthood, our brains become more stable and rigid when compared to that of an adolescent. This is partially due to the triggering of a single gene that slows the rapid change in synaptic connections between neurons, thereby suppressing the high levels of plasticity of an adolescent brain.
Metoprolol had already been identified by me as a life extending drug based on two human RCTs which reported mortality reductions in hypertensives that exceeded the standard mortality rate, as well as the control groups. PMID: 3293400, PMID: 1682683.
There is no indication that these hypertensives should have mortality rates better than the general population, therefore the bettering of the standard mortality rates makes these drugs anti-aging.
THE BENEFIT IS ABOUT 45% EQUALING BETTER THAN A SIX YEAR LIFE EXTENSION FOR HUMANS
"We actually delayed the onset of aging and extended the healthy lifespan," Zhou said of the mice.
Mice with progeria lived 30 percent longer when fed with resveratrol compared with progerial mice not given the compound.
Asked if their study supported the notion that drinking red wine delays aging and reduces the risk of heart disease, Zhou said the alcohol content in wine would cause harm before any benefit could be derived.
Aubrey de Grey, Chief Science Officer of SENS Foundation and the world’s most prominent advocate of anti-aging research, argues that it makes no sense to spend the vast majority of our medical resources on trying to combat the diseases of aging without tackling aging itself, writes ethicist Peter Singer on Project Syndicate.
De Grey believes that even modest progress in this area over the coming decade could lead to a dramatic extension of the human lifespan.
Ray and Terry's 's insight:
We are working towards a point in history when we can add a year to life expectancy for every year we age.
To survey previously uncharted territory, a team of researchers at UW-Madison has created an “atlas” that maps more than 1,500 unique landmarks within mitochondria that could provide clues to the metabolic connections between caloric restriction and aging.
The map, as well as the techniques used to create it, could lead to a better understanding of how cell metabolism is rewired in some cancers, age-related diseases and metabolic conditions such as diabetes.
Omega-3 fatty acid supplementation lowered the concentration of inflammatory cytokines in a research study. The data incdicates that maintaining a healthy (higher) ratio of omega-3: omega-6 fats can reduce the impact of aging on cellular health.
Inflammation, oxidative stress, and immune cell aging together lead to higher incidence of disease. Nutritional supplementation, including omega-3s can impact and reduce this damage.
SIRT1, a protein that slows aging in mice and other animals, also protects against the ravages of a high-fat diet, including diabetes, according to a new MIT study.
Nokia is sponsoring the Nokia Sensing X CHALLENGE. The US$2.25 million global competition is intended to “stimulate the development of sensors and sensing technology to drastically improve and expand the quality and access to healthcare across a wide variety of settings for consumers all around the globe.
Teams are required to submit a system, device, or component that can detect a physical value and record or interpret it. Those physical values could be applied to things such as biofluid and tissue samples, bodily structures, a patient’s external environment, body movements, mood/emotion, and body physics – that last category would include the measurement of vital signs such as heart rate, blood pressure, and respiratory rate.
NEW YORK (Reuters Health) - Older adults who are at high risk of falls should have physical therapy and take vitamin D supplements to reduce their chance of injury, according to new recommendations from...
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